Weight loss hasan ending.Maintenance does not.
01 — The problem
Discontinuationleads to rapidweight regain.
Up to 68% of lost weight returns within 12 months of stopping chronic GLP-1 therapy. The category has optimised for weight loss, and almost entirely ignored what comes next.
Weight regain within 12 months after GLP-1 cessation
Real-world persistence on chronic GLP-1 therapies at 12 months
02 — Our solution
On-demand,short-acting maintenance.
Metabexa is developing the first on-demand GLP-1 maintenance platform — a short-acting, oral mucosal therapy designed for situational appetite control, not weight loss.
Pre-meal, patient-controlled
i
On-demand dosing
Patient-controlled dosing 15–60 minutes before a planned meal. No daily injections, no chronic commitment — the patient initiates the dose.
ii
Short-acting profile
Rapid onset (Tmax < 90 min) and rapid offset (4–6 hours). The pharmacokinetic profile is built around the hunger-spike timeframe.
iii
Oral mucosal delivery
Buccal or sublingual delivery bypasses first-pass metabolism for predictable, peptide-friendly absorption — and a non-injection ritual.
For the meal,not for life.
03 — Scientific rationale
A known peptide.A new delivery.
We’re not inventing a new GLP-1 receptor agonist. We use a known, de-risked peptide with proven short-acting precedents — exenatide, lixisenatide. The innovation is in the delivery: oral mucosal administration, optimised for an on-demand profile.
04 — Category creation
Maintenance is a distincttherapeutic category.
Weight loss requires metabolic shock. Maintenance requires behavioural control. Two different problems, two different pharmacologies.
Goal
Weight lossMaximal weight reduction
MaintenancePrevent regain, control appetite
Dosing
Weight lossChronic, weekly injection
MaintenanceOn-demand, situational
Duration
Weight lossIndefinite
MaintenanceEpisodic — hours, not weeks
Patient control
Weight lossLow — locked into a regimen
MaintenanceHigh — patient initiates the dose
A new chapter
On,on your terms.
05 — Get in touch
Partner with us.
We’re seeking strategic partners, investors and collaborators to advance the first on-demand GLP-1 maintenance platform.